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What is the blood brain barrier and what drugs are capable of crossing it?
If anybody can help me out with this subject matter, that would be great! I know the blood brain barrier is a tight seal of endothelial cells that prevents many chemical substances and bacteria from entering the brain. (is there anything else I shoould know about it?) Also, what kind of drugs are able to penetrate the blood brain barrier? I know highly lipid soluble drugs can, but are there any others? In addition, what is the reason for these drugs to be able to cross it? What are the implications for this?
Thank you to anyone who can help. It's GREATLY appreciated.
General Properties of the BBB:
-Large molecules do not pass through the BBB easily.
-Low lipid (fat) soluble molecules do not penetrate into the brain.
-Molecules that have a high electrical charge are slowed.
There are plenty of medications that cross the BBB, and all recreational drugs do as well.
The reason these drugs can cross it is because the brain has to let SOME things pass into it (glucose, oxygen, etc) but also has to keep things out (bacteria), so these are the rules it sets up to let everything the brain needs pass through, while minimizing the amount of other chemicals that can pass. The drugs that we have are just loopholes that still meet the chemical requirements.
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